Innovative drug product development
Drug development services


"Pilot Bioavailability Study of a novel Bisphosphonate Osteotropic Drug Delivery System by oral route, for metastatic bone treatment" Th. Breul / S. Silva-Lejmi / S. Rizea-Savu / L. Silvestro - presented at the 8th Oncology Days, October 10 – 12 2012 in Montpellier France.

PIlot bioavailability study

"Bisphosphonate based Osteotropic Drug Delivery System for metastatic bone treatment by oral route" Th. Breul, S. Silva-Lejmi, S. Rizea-Savu, L. Silvestro. 2nd Symposium on Drug Delivery Sytems, Nanjing, November 8, 2012


"Stabilization of rasburicase and physico-chemical characterization of the resulting injectable formulation" Bayol A. / Breul T. / Dupin P. / Menegotto J. / Aleman C. / Duplaa H. / Faure P. / Bonnet M.C. / Bauer M. - Drug Development and Industrial Pharmacy Vol.30, N°8 pp 877-889, 2004.

"Effect of citric acid on Xaliproden / β-cyclodextrin complex properties determined by two-dimensional NMR and isothermal titration microcalorimetry" Bonnel, M. / Breul, T. / Gautier, J.C. - 11th International Cyclodextrin symposium, Reykjavik, May 2002.

"Formulation of a stable pharmaceutical injectable composition containing a protein : Rasburicase a case study" Bayol, A. / Breul, T. - 3rd International conference on protein stabilisation, Toulouse, April 2002

"Stoichiometry and thermodynamic parameters determination of interactions between Dronedarone, Xaliproden and different solubilizers using isothermal titration microcalorimetry" Breul, T. / Bonnel, M. / Ghirlando, R. / Saudemon, P. - World conference on drug absorption and drug delivery, Copenhagen 2001

"Physico-chemical characterization and pharmacological properties of different cyclodextrin complexes of a platelet activating factor receptor antagonist : SR27417A" Breul, T. / Caron, A. / Gautier, J.C. / Herbert, J.M. / Ghirlando, R. / Perly, B. / Saudemon, P. - 9th International symposium on cyclodextrins, Santiago de Compostella, 1998

"Influence of the formulation physico-chemical properties on the in vitro percutaneous penetration of testosterone" Illel, B. / Villeger, I. / Monginoux, P. / Breul, T. - In Prediction of Percutaneous Penetration 4th International Conference. La Grande Motte, April. 1995

"Sodium lauryl sulphate increases tiludronate paracellular transport using human epithelial Caco-2 monolayers" Boulenc, X. / Breul, T. / Gautier, J.C. / Saudemon, P. / Joyeux, H. / Roques, C. / Berger, Y. / Fabre, G. - International Journal of Pharmaceutics. 123 (1995) 71-83123 (1995) 71-83

"Microemulsion formulation rules : a tool to determine the effect of vehicles and penetration enhancers on percutaneous drug transport." Breul, T. / Marrier, J.M. / Gautier, J.C. - In Prediction of Percutaneous Penetration 3rd International Conference, La Grande Motte. 1993

"Etude de l’influence des variables de formulation sur les propriétés moussantes des systèmes liquides polyphasés" Breul, T. - Thèse de doctorat, spécialité: Chimie-Physique, Institut National Polytechnique de Toulouse. 1992

"Foaming properties of surfactant-oil-water systems in the neighbourhood of optimum formulation" Lachaise, J. / Breul, T. / Graciaa, A. / Marion, G. / Monsalve, A. / Salager, J.L. - Journal of Dispersion Science and Technology. Vol. 11 (5) 443-455. 1990

"Etnobotanica de los Makiritare" Sugden, A. / Breul, T. / De Civrieux, M. - In " El hombre silvestre ante la naturaleza" Monte Avila Ed. Caracas, Venezuela. 1989

"Influence of the physico-chemical formulation on the foaming properties of surfactant-oil-water systems in the neighbourhood of three phase behavior" Lachaise, J. / Breul, T. / Graciaa, A. / Marion, G. / Monsalve, A. / Salager, J.L. - Third European Colloid and Interface Society Conference. Basel (CH) Sept. 1989

"Two dimensional displacement of oil by gas and surfactant solution under foaming conditions" Breul, T./ J.B. / Ph. D. - dissertation, Stanford University Petroleum Research Institute, Stanford, California. 1988

"Efecto de la viscosidad interfacial en la espumabilidad y estabilidad de espumas de sistemas liquidos" Breul, T. / Villabona, J. / Monsalve, A. - IV congreso Venezolano de Ingenieria Quimica. 1987 Caracas. Venezuela.

"Relación entre el comportamento de fases de sistemas salmuear-aceite-surfactante-alcohol y la generación y estabilidad de espumas" Breul, T. / Monsalve, A. / Salager, J.L. - II SIREMCRU, Maracaibo, Feb. 24-27. 1987

"Poder espumante y estabilidad de espumas de sistemas multifasicos: salmuear-aceite-surfactante-alcohol" Breul, T. / Salager, J.L. / Monsalve, A. - XXXVI Convencion anual de ASOVAC. Valencia 16-21 Nov. 1986

"Determination of protein digestibility of various distillers by-products using an in vitro multi-enzyme UV method" Breul, T. / Näsi, M. - Journal of Agricultural Science in Finland. Vol 59. 151-162. 1986